2267287-26-1
2267287-26-1 structure
- Name: Icapamespib HCl
- Chemical Name: Icapamespib HCl
- CAS Number: 2267287-26-1
- Molecular Formula: C19H25Cl2IN6O2S
- Molecular Weight: 599.31
- Create Date: 2025-09-19 12:07:42
- Modify Date: 2025-09-19 12:07:42
-
Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans.
| Name | Icapamespib HCl |
|---|
| Description | Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. |
|---|
| Molecular Formula | C19H25Cl2IN6O2S |
|---|---|
| Molecular Weight | 599.31 |