2937344-16-4
2937344-16-4 structure
- Name: BI-2493
- Chemical Name: BI-2493
- CAS Number: 2937344-16-4
- Molecular Formula: C24H27N7OS
- Molecular Weight: 461.58
- Catalog: Signaling Pathways GPCR/G Protein Ras
- Create Date: 2024-01-30 06:49:16
- Modify Date: 2024-01-30 06:49:16
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BI-2493 is a non-covalent and pan KRAS inhibitor. BI-2493 inhibits the interaction of GDP-bound KRAS with SOS1 in a biochemical assay using recombinant proteins with IC50s < 11nM. BI-2493 can be used in studies about KRAS-driven cancers.
| Name | BI-2493 |
|---|
| Description | BI-2493 is a non-covalent and pan KRAS inhibitor. BI-2493 inhibits the interaction of GDP-bound KRAS with SOS1 in a biochemical assay using recombinant proteins with IC50s < 11nM. BI-2493 can be used in studies about KRAS-driven cancers. |
|---|---|
| In Vitro | BI-2493 inhibits the proliferation with IC50 values < 140 nM in Ba/F3 cell lines made dependent on KRAS by transfection of different mutant KRAS oncogenes (e.g., KRAS G12C, KRAS G12D, KRAS G12V)[1]. |
| In Vivo | BI-2493(90 mg/kg; gavage) attenuats tumour growth in mice bearing KRAS G12C, G12D, G12V and A146V mutant models, without causing apparent toxicity to the mice[1]. |
| References | 1. Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023 Jul;619(7968):160-166. |
| Molecular Formula | C24H27N7OS |
|---|---|
| Molecular Weight | 461.58 |