2278265-85-1

2278265-85-1 structure

Name: DNL343
Chemical Name: DNL343
CAS Number: 2278265-85-1
Molecular Formula: C₂₀H₁₉ClF₃N₃O₄
Molecular Weight: 457.83
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2023-11-07 16:59:56
Modify Date: 2024-01-04 16:31:05
DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation[1].

Name	DNL343

Description	DNL343 is a brain-penetrating activator of eukaryotic initiation factor 2B (eIF2B) that inhibits the abnormal integrated stress response (ISR). DNL343 inhibits ISR activity in the central nervous system (CNS) and reverses neurodegeneration and neuroinflammation. DNL343 also prevents motor dysfunction and premature death in eIF2B loss-of-function (LOF) mutant mice. DNL343 has inhibitory potential in studies of vanishing white matter disease (VWMD) driven by eIF2B LOF and chronic ISR activation[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF) Research Areas >> Neurological Disease
Target	eIF2B, integrated stress response (ISR)[1]
References	[1]. Yulyaningsih E, et al. DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration caused by the Integrated Stress Response[J]. bioRxiv, 2023: 2023.8.21.554203

Molecular Formula	C₂₀H₁₉ClF₃N₃O₄
Molecular Weight	457.83