878027-87-3

878027-87-3 structure

Name: αA-Conotoxin OIVA
Chemical Name: αA-Conotoxin OIVA
CAS Number: 878027-87-3
Molecular Formula: C₇₀H₁₁₀N₂₄O₂₃S₆
Molecular Weight: 1848.16
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2023-11-11 00:18:11
Modify Date: 2026-08-24 15:26:02
αA-Conotoxin OIVA (αA-OIVA) is a selective nAChR antagonist with an IC50 of 56 nM against mammalian fetal muscle nAChR. αA-Conotoxin OIVA is a peptide that can be derived from conotoxin. αA-Conotoxin OIVA paralyzes muscles[1][2].

Name	αA-Conotoxin OIVA
Synonyms	L-Cysteinamide, L-cysteinyl-L-cysteinylglycyl-L-valyl-(4R)-4-hydroxy-L-prolyl-L-aspaginyl-L-alanyl-L-alanyl-L-cysteinyl-L-histidyl-(4R)-4-hydroxy-L-prolyl-L-cysteinyl-L-valyl-L-cysteinyl-L-lysyl-L-aspaginyl-L-threonyl-, cyclic (1→9),(2→14),(12→18)-tris(disulfide)

Description	αA-Conotoxin OIVA (αA-OIVA) is a selective nAChR antagonist with an IC50 of 56 nM against mammalian fetal muscle nAChR. αA-Conotoxin OIVA is a peptide that can be derived from conotoxin. αA-Conotoxin OIVA paralyzes muscles[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
References	[1]. Teichert RW, et al. A uniquely selective inhibitor of the mammalian fetal neuromuscular nicotinic acetylcholine receptor. J Neurosci. 2005 Jan 19;25(3):732-6. [2]. Teichert RW, et al. AlphaA-Conotoxin OIVA defines a new alphaA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors. Toxicon. 2004 Aug;44(2):207-14.

Molecular Formula	C₇₀H₁₁₀N₂₄O₂₃S₆
Molecular Weight	1848.16