1189865-34-6

1189865-34-6 structure

Name: Diethyl (2H9)butylmalonate
Chemical Name: Diethyl 2-n-Butylmalonate-d9
CAS Number: 1189865-34-6
Molecular Formula: C₁₁H₁₁D₉O₄
Molecular Weight: 225.330
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-15 10:30:59
Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate[1]. Diethyl butylmalonate exhibits toxicity to T. pyriformis, with a log(IGC50-1) of 0.557[2].

Name	Diethyl 2-n-Butylmalonate-d9
Synonyms	Diethyl (H)butylmalonate Propanedioic acid, 2-(butyl-d)-, diethyl ester diethyl 2-(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)propanedioate

Description	Diethyl butylmalonate-d9 is the deuterium labeled Diethyl butylmalonate[1]. Diethyl butylmalonate exhibits toxicity to T. pyriformis, with a log(IGC50-1) of 0.557[2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. T I Netzeva, et al. Partial least squares modelling of the acute toxicity of aliphatic compounds to Tetrahymena pyriformis. SAR QSAR Environ Res. 2003 Aug;14(4):265-83.