832115-62-5

832115-62-5 structure

Name: Isoxazole 9 (ISX-9)
Chemical Name: N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
CAS Number: 832115-62-5
Molecular Formula: C₁₁H₁₀N₂O₂S
Molecular Weight: 234.274
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2017-05-14 02:12:01
Modify Date: 2024-01-08 13:50:33
ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.

Name	N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide
Synonyms	N-Cyclopropyl-5-(2-thienyl)-1,2-oxazole-3-carboxamide 3-Isoxazolecarboxamide, N-cyclopropyl-5-(2-thienyl)- ISX 9 Isoxazole 9 ISX-9

Description	ISX-9 is a small molecule inducer of adult neural stem cell differentiation. Target: At 2.5-20 μM, ISX-9 has been shown to dose-dependently trigger neurogenesis and block gliogenesis in adult rat hippocampal stem cells through a calcium-activated signaling pathway dependent on myocyte-enhancer factor 2-dependent gene expression.ISX-9 administered at 20 mg/kg for 12 days to mice has been reported to improve hippocampal function as evidenced by enhanced spatial memory ability in the Morris water maze test.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Petrik D, et al. Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J. 2012 Aug;26(8):3148-3162.

90924-54-2

765-30-0

~62%

832115-62-5

Literature: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM Patent: US2009/36451 A1, 2009 ; Location in patent: Page/Page column 32 ;

Precursor 2
90924-54-2 765-30-0
DownStream 0