2983118-29-0

2983118-29-0 structure

Name: GPR139 agonist-2
Chemical Name: GPR139 agonist-2
CAS Number: 2983118-29-0
Molecular Formula: C₁₇H₁₅F₃N₄O₃
Molecular Weight: 380.32
Catalog: Signaling Pathways GPCR/G Protein GPR139
Create Date: 2023-12-26 22:06:13
Modify Date: 2026-06-30 17:06:16
GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1].

Name	GPR139 agonist-2
Synonyms	Pyrrolo[1,2-d][1,2,4]triazine-3(4H)-acetamide, 4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]

Description	GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR139 Research Areas >> Neurological Disease
References	[1]. Jianhang Mao, et al. Design and Synthesis of Novel GPR139 Agonists with Therapeutic Effects in Mouse Models of Social Interaction and Cognitive Impairment. J Med Chem. 2023 Oct 26;66(20):14011-14028.

Molecular Formula	C₁₇H₁₅F₃N₄O₃
Molecular Weight	380.32