Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: proflavine
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92-62-6

92-62-6 structure

Name: Proflavine
Chemical Name: 3,6-diaminoacridine
CAS Number: 92-62-6
Molecular Formula: C₁₃H₁₁N₃
Molecular Weight: 209.24700
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2016-07-12 03:41:31
Modify Date: 2026-07-01 19:28:50
Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].

Name	3,6-diaminoacridine
Synonyms	Proflavine, 10 mM in DMSO PROFLAVINE 6-Diaminoacridine acridine-3,6-diamine Inhibitor,Proflavine,Whole,Bacterial,blood,inwd,inhibit,channel,rectifier,G protein,gated Isoflabase 3,6-Diamino-5-cyan-1-methyl-1H-pyrazolo<3,4-b>pyridin 3,6-Acridinediamine 3,6-Aiaminoacridine (6-aminoacridin-3-yl)amine 3,6-Diamino-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile

Description	Proflavine, an acridine dye, is a known DNA intercalating agent. Anti-microbial agent[1]. Proflavine behaves as a pore blocker for Kir3.2. Proflavine is a potential lead compound for Kir3.2-associated neurological diseases[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278. [2]. Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28. [3]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

Density	1.346 g/cm3
Boiling Point	506.9ºC at 760 mmHg
Melting Point	260ºC
Molecular Formula	C₁₃H₁₁N₃
Molecular Weight	209.24700
Flash Point	292.9ºC
Exact Mass	209.09500
PSA	64.93000
LogP	3.71480
Index of Refraction	1.833

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR8670000

CHEMICAL NAME :: Acridine, 3,6-diamino-

CAS REGISTRY NUMBER :: 92-62-6

BEILSTEIN REFERENCE NO. :: 0166050

LAST UPDATED :: 199806

DATA ITEMS CITED :: 42

MOLECULAR FORMULA :: C13-H11-N3

MOLECULAR WEIGHT :: 209.27

WISWESSER LINE NOTATION :: T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 11111 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 13500 nmol/L

REFERENCE :: ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 67,127,1965 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6466 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 621 (estimated)

HS Code	2933990090

Precursor 8
952-23-8 26946-33-8 108-45-2 101-22-4
42832-87-1 101-77-9 56-81-5 144-62-7
DownStream 7
15724-70-6 113110-49-9 74165-99-4 103900-67-0
43129-74-4 581-29-3 63676-40-4

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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