127697-58-9

127697-58-9 structure

Name: N-(4-Ethoxyphenylcarbonyl)-1,1,4,4-tetramethyltetralin-6-carboxamide
Chemical Name: ethyl 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoate
CAS Number: 127697-58-9
Molecular Formula: C₂₄H₂₉NO₃
Molecular Weight: 379.49200
Catalog: Research Areas Others
Create Date: 2017-01-04 07:02:19
Modify Date: 2024-01-15 09:18:44
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2].

Name	ethyl 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoate
Synonyms	sri 6409-94

Description	SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	SRI 6409-94 causes virgin female outbred syrian golden hamciasters to produce deformed offspring, in a dose-dependent manner[1]. SRI 6409-94 leads to reductions in mean fetal body weight and in the numbers of ossified skeletal districts, significantly[1].
References	[1]. Willhite CC, et al. Structure-activity relationships of retinoids in developmental toxicology. IV. Planar Cisoid conformational restriction. Toxicol Appl Pharmacol. 1990 Apr;103(2):324-44. [2]. Willhite CC, et al. Structure-affinity relationships of retinoids with embryonic cellular retinoic acid-binding protein. Toxicol Appl Pharmacol. 1992 Jan;112(1):144-53.