356066-46-1

356066-46-1 structure

Name: m-PEG3-aldehyde
Chemical Name: 3-[2-(2-methoxyethoxy)ethoxy]propanal
CAS Number: 356066-46-1
Molecular Formula: C₈H₁₆O₄
Molecular Weight: 176.21000
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-03-01 06:36:40
Modify Date: 2024-01-08 12:16:34
m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name	3-[2-(2-methoxyethoxy)ethoxy]propanal

Description	m-PEG3-aldehyde is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. The binding affinities of anti-mPEGs depend more on the backbone lengths of the polymers and the hydrophobicities of their end-groups than on their resemblance to the methoxy terminus of the immunogenic polymer[1]. Aldehyde is reactive to hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The hydrophilic PEG spacer increases solubility in aqueous media.
References	[1]. Saifer MG, et al.Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins.Mol Immunol. 2014 Feb;57(2):236-46.