59163-53-0

59163-53-0 structure

Name: Aloenin aglycone
Chemical Name: 6-(2,4-dihydroxy-6-methylphenyl)-4-methoxypyran-2-one
CAS Number: 59163-53-0
Molecular Formula: C₁₃H₁₂O₅
Molecular Weight: 248.23100
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2016-11-05 10:48:12
Modify Date: 2024-01-08 18:31:00
Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].

Name	6-(2,4-dihydroxy-6-methylphenyl)-4-methoxypyran-2-one
Synonyms	4-methoxy-6-(2',4'-dihydroxy-6'-methylphenyl)pyran-2-one Aloenin-Aglycon 6-(2',4'-dihydroxy-6'-methylphenyl)-4-methoxy-2-pyrone 6-(2,4-dihydroxy-6-methyl-phenyl)-4-methoxy-pyran-2-one 2H-Pyran-2-one,6-(2,4-dihydroxy-6-methylphenyl)-4-methoxy aloenin aglycone

Description	Aloenin aglycone (compound 13) is an NF-κB inhibitor that can be isolated from aloe exudate. Aloenin aglycone inhibits TNFα-induced NF-κB transcriptional activity (IC50: 18.7 μM). Aloenin aglycone (10 μM) also reduced inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) gene expression after treatment of HepG2 cells with 10 ng/mL TNFα[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Target	intercellular adhesion molecule-1 (ICAM-1)[1]
References	[1]. Sun Y N, et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239. [2]. Sun Y N. et al. Isolation and identification of chromone and pyrone constituents from Aloe and their anti-inflammatory activities[J]. Journal of Functional Foods, 2016, 21: 232-239.