916734-43-5

916734-43-5 structure

Name: TC-I 15
Chemical Name: L-Alanine, N-[[(4R)-5,5-dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]
CAS Number: 916734-43-5
Molecular Formula: C₂₃H₂₈N₄O₆S₂
Molecular Weight: 520.62
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2016-04-04 19:17:41
Modify Date: 2024-01-12 18:08:41
TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].

Name	L-Alanine, N-[[(4R)-5,5-dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]
Synonyms	Piclamilast

Description	TC-I 15 (TC-I-15) is an allosteric, collagen-binding integrin α2β1 inhibitor with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Cytoskeleton >> Integrin
Target	α2β1:0.4 (α2β1 μM (IC50) α2β1:26.8 (α2β1 μM (IC50) α1β1:23.6 (α1β1 μM (IC50) α1β1:24.4 (α1β1 μM (IC50) α11β1:177 (α11β1 μM (IC50) α11β1:3177 (α11β μM (IC50)
References	[1]. Emma J. Hunter, Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol Appl Pharmacol. 2021 Oct 1;428:115669.