81381-50-2

81381-50-2 structure

Name: (D-Ala4)-Substance P (4-11)
Chemical Name: [D-Ala4]-Substance P (4-11)
CAS Number: 81381-50-2
Molecular Formula: C₄₄H₆₅N₁₁O₁₀S
Molecular Weight: 940.120
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2018-12-31 21:10:48
Modify Date: 2024-01-10 19:40:54
[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1].

Name	[D-Ala4]-Substance P (4-11)
Synonyms	D-Alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide Substance P,fragment 4-11,(D-Ala4) D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 H-D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 L-Methioninamide, D-alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- SUBSTANCE P OCTAPEPTIDE D-ALA-4-FRAGMENT 4-11) (D-ALA4)-SUBSTANCE P (4-11)

Description	[DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	Eledoisin 和 Substance P 是速激肽的一类肽成员，它们具有相似的生物活性谱。[DAla4] Substance P (4-11) ([D-Ala0-(5-11)]SP) 抑制 125I-Bolton Hunter-conjugated 偶联的 Eledoisin 和 125I-Bolton Hunter 偶联的 Substance P 与大鼠大脑皮层膜的结合[1]。
References	[1]. M A Cascieri, et al. Demonstration of two distinct tachykinin receptors in rat brain cortex. J Biol Chem. 1985 Feb 10;260(3):1501-7.