86220-42-0
86220-42-0 structure
- Name: nafarelin acetate
- Chemical Name: 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-3-(2-naphthyl)-d-alanyl-l-leucyl-l-arginyl-l-prolylglycinamide acetate hydrate
- CAS Number: 86220-42-0
- Molecular Formula: C68H89N17O16
- Molecular Weight: 1400.54000
- Create Date: 2018-03-27 08:00:00
- Modify Date: 2025-08-25 13:27:18
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Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF. It is normally delivered via a nasal spray. Nafarelin acetate is marketed by Searle (now part of Pfizer) under the brand name Synarel.
| Name | 5-oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-3-(2-naphthyl)-d-alanyl-l-leucyl-l-arginyl-l-prolylglycinamide acetate hydrate |
|---|---|
| Synonyms |
nafarelin acetate hydrate
nafarelin acetate MFCD00895733 |
| Boiling Point | 1840.1ºC at 760 mmHg |
|---|---|
| Molecular Formula | C68H89N17O16 |
| Molecular Weight | 1400.54000 |
| Flash Point | 1066.6ºC |
| Exact Mass | 1399.67000 |
| PSA | 518.66000 |
| LogP | 3.89850 |
| Vapour Pressure | 0mmHg at 25°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |