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40680-87-3

40680-87-3 structure
40680-87-3 structure
  • Name: Piprofurol
  • Chemical Name: 4-[3-[4,7-dimethoxy-6-(2-piperidin-1-ylethoxy)-1-benzofuran-5-yl]-3-hydroxypropyl]phenol
  • CAS Number: 40680-87-3
  • Molecular Formula: C26H33NO6
  • Molecular Weight: 455.54300
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
  • Create Date: 2018-02-11 08:00:00
  • Modify Date: 2024-01-04 14:42:59
  • Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
Name 4-[3-[4,7-dimethoxy-6-(2-piperidin-1-ylethoxy)-1-benzofuran-5-yl]-3-hydroxypropyl]phenol
Synonyms EINECS 255-035-6
Piprofurol
Piprofurol [INN]
Piprofurolum
Piprofurolum [INN-Latin]
1-[4,7-dimethoxy-6-(2-piperidin-1-yl-ethoxy)-benzofuran-5-yl]-3-(4-hydroxy-phenyl)-propan-1-ol
Description Piprofurol is a calcium channel inhibitor. Piprofurol inhibites in a concentration-dependent manner the calcium-induced contractions in isolated potassium depolarized preparations of rat aorta and relaxes the K+-induced contraction of the dog coronary artery and the rabbit basilar artery. Piprofurol exerts a negative inotropic effect on guinea-pig papillary muscle, with the EC50 of 5 μM[1].
Related Catalog
Target

5 μM(guinea-pig papillary muscle)[1]

References

[1]. Pourrias B, et al. Calcium blocking properties of piprofurol. Arch Int Pharmacodyn Ther. 1985;274(2):223-239.  

Density 1.214g/cm3
Boiling Point 640.7ºC at 760 mmHg
Molecular Formula C26H33NO6
Molecular Weight 455.54300
Flash Point 341.3ºC
Exact Mass 455.23100
PSA 84.53000
LogP 4.62440
Index of Refraction 1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DF6845120
CHEMICAL NAME :
5-Benzofuranmethanol, 4,7-dimethoxy-alpha-(2-(4-hydroxyphenyl)ethyl)-6- (2-(1-piperidinyl)ethoxy)-
CAS REGISTRY NUMBER :
40680-87-3
BEILSTEIN REFERENCE NO. :
1276232
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C26-H33-N-O6
MOLECULAR WEIGHT :
455.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JNPHAG Journal de Pharmacologie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1970- Volume(issue)/page/year: 8,125,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 9,85,1974

Chemsrc provides CAS#:40680-87-3 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 40680-87-3 | Chemsrc address: https://m.chemsrc.com/en/baike/247974.html

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