838823-31-7

838823-31-7 structure
838823-31-7 structure
  • Name: TCS 2312
  • Chemical Name: [1,1'-Biphenyl]-2,4-diol, 4'-[5-[[4-[(cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]
  • CAS Number: 838823-31-7
  • Molecular Formula: C25H24N4O2
  • Molecular Weight: 412.48
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Checkpoint Kinase (Chk)
  • Create Date: 2016-01-11 17:37:54
  • Modify Date: 2024-08-26 21:17:59
  • CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].

Name [1,1'-Biphenyl]-2,4-diol, 4'-[5-[[4-[(cyclopropylamino)methyl]phenyl]amino]-1H-pyrazol-3-yl]
Synonyms TCS 2312
Anpirtoline hydrochloride
Description CHK1-IN-7 (Compound 10c) is a potent human CHK1 inhibitor. CHK1-IN-7 shows no single agent effect, potentiates the antiproliferative effect of Gemcitabine HY-17026 in both prostate and breast cancer cell lines. CHK1-IN-7 can be used for the research of cancer[1].
Related Catalog
References

[1]. Teng M, et al. Structure-based design and synthesis of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2',4'-diols as novel and potent human CHK1 inhibitors. J Med Chem. 2007 Nov 1;50(22):5253-6.  

Molecular Formula C25H24N4O2
Molecular Weight 412.48
Exact Mass 412.19000
PSA 93.20000
LogP 5.61440