34354-88-6
34354-88-6 structure
- Name: C18 Phytoceramide (t18:0/18:0)
- Chemical Name: N-Stearoyl Phytosphingosine
- CAS Number: 34354-88-6
- Molecular Formula: C36H73NO4
- Molecular Weight: 583.96900
- Catalog: Research Areas Others
- Create Date: 2017-06-23 22:15:35
- Modify Date: 2024-01-07 17:31:38
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C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.
| Name | N-Stearoyl Phytosphingosine |
|---|---|
| Synonyms | N-[(3S)-1,3,4-Trihydroxy-2-octadecanyl]octadecanamide |
| Description | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation. |
|---|---|
| Related Catalog |
| Molecular Formula | C36H73NO4 |
|---|---|
| Molecular Weight | 583.96900 |
| Exact Mass | 583.55400 |
| PSA | 93.28000 |
| LogP | 10.37830 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|---|
| HS Code | 2924199090 |
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34354-88-6 |
| Literature: EVONIK GOLDSCHMIDT GMBH Patent: US2011/77302 A1, 2011 ; Location in patent: Page/Page column 9 ; |
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~95%
34354-88-6 |
| Literature: Kimura, Akiyoshi; Imamura, Akihiro; Ando, Hiromune; Ishida, Hideharu; Kiso, Makoto Synlett, 2006 , # 15 p. 2379 - 2382 |
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34354-88-6 |
| Literature: EVONIK GOLDSCHMIDT GMBH Patent: US2011/77302 A1, 2011 ; Location in patent: Page/Page column 9 ; |
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34354-88-6 |
| Literature: Chang, Young-Tae; Choi, Jaehwa; Ding, Sheng; Prieschl, Eva E.; Baumruker, Thomas; Lee, Jae-Mok; Chung, Sung-Kee; Schultz, Peter G. Journal of the American Chemical Society, 2002 , vol. 124, # 9 p. 1856 - 1857 |
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34354-88-6 |
| Literature: EVONIK GOLDSCHMIDT GMBH Patent: US2011/77302 A1, 2011 ; Location in patent: Page/Page column 8 ; |
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34354-88-6 |
| Literature: EVONIK GOLDSCHMIDT GMBH Patent: US2011/77302 A1, 2011 ; |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |