53177-12-1
53177-12-1 structure
- Name: MANGANESE, CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KN)METHYLIDYNE]]BIS[PHENOLATO-KO]](2-)]-, (SP-5-13)-
- Chemical Name: manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
- CAS Number: 53177-12-1
- Molecular Formula: C16H14ClMnN2O2
- Molecular Weight: 356.686
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-12-25 18:21:19
- Modify Date: 2024-01-09 22:52:29
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Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2].
| Name | manganese(3+),2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride |
|---|---|
| Synonyms |
euk-8
1,2-bis(salicylideneamino)ethane manganese(III) chloride 2-[2-[(2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate Manganese,chloro((2,2'-(1,2-ethanediylbis(nitrilomethylidyne))bis(phenolato))(2-)-N,N',O,O')-,(SP-5-13) Mn(salen)Cl chloro-[N,N'-bis(salicylidene)ethylenediaminato]manganese(III) N,N'-Bis(salicylidene)-1,2-ethylenediamine-manganese(II) [manganese(III)Cl(N,N'-bis(salicylidene) ethylenediamine)] Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}diphenolate (1:1:1) [2,2'-[ethane-1,2-diil-bis(nitrilo-methylidyne)]diphenolato]-manganese(III)-chloride Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis-, manganese(3+) salt, hydrochloride (1:1:1) N,N'-Bis(salicylideneamino)ethane-manganese(II) (N,N'-ethylenebis(salicylideneaminato))MnCl Salen-manganese complex |
| Description | Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation[2]. |
| In Vivo | Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant[3]. Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice[3] Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis. |
| References |
| Boiling Point | 448.8ºC at 760mmHg |
|---|---|
| Molecular Formula | C16H14ClMnN2O2 |
| Molecular Weight | 356.686 |
| Flash Point | 294.1ºC |
| Exact Mass | 356.012421 |
| PSA | 70.84000 |
| LogP | 0.51620 |
| Storage condition | -20°C |
| RIDADR | NONH for all modes of transport |
|---|