41332-24-5
41332-24-5 structure
- Name: NP118809
- Chemical Name: 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one
- CAS Number: 41332-24-5
- Molecular Formula: C32H32N2O
- Molecular Weight: 460.609
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2017-06-18 01:13:21
- Modify Date: 2024-01-11 17:38:04
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NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
| Name | 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one |
|---|---|
| Synonyms |
1-benzhydryl-4-(3,3-diphenyl-propionyl)-piperazine
1-[4-(Diphenylmethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone 1-Propanone, 1-[4-(diphenylmethyl)-1-piperazinyl]-3,3-diphenyl- 1-(4-Benzhydryl-piperazin-1-yl)-3,3-diphenyl-propan-1-one 1-(3,3-diphenylpropionyl)-4-benzhydryl piperazine NP-118809 NP118809 |
| Description | NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM. |
|---|---|
| Related Catalog | |
| Target |
N-Type Ca2+ Channel:0.11 μM (IC50) L-type calcium channel:12.2 μM (IC50) |
| In Vitro | NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also inhibits L-type calcium channel with an IC50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC50 of 7.4 μM[1]. |
| In Vivo | NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model[1]. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model[2]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 618.9±55.0 °C at 760 mmHg |
| Molecular Formula | C32H32N2O |
| Molecular Weight | 460.609 |
| Flash Point | 251.4±23.9 °C |
| Exact Mass | 460.251465 |
| PSA | 23.55000 |
| LogP | 6.51 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.622 |
| Storage condition | 2-8℃ |
|
~77%
41332-24-5 |
| Literature: Neuromed Technologies, Inc. Patent: US6951862 B2, 2005 ; US 6951862 B2 |
