147700-11-6

147700-11-6 structure

Name: 8-(3-Chlorostyryl)caffeine
Chemical Name: 8-(3-chlorostyryl)caffeine
CAS Number: 147700-11-6
Molecular Formula: C₁₆H₁₅ClN₄O₂
Molecular Weight: 330.76900
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-02-26 16:45:31
Modify Date: 2025-08-25 19:06:13
(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits monoamine oxidase B (MAO-B) with a Ki value of 70 nM by a pathway that is independent of its actions on the A2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson's disease research[1].

Name	8-(3-chlorostyryl)caffeine
Synonyms	(E)-8-(3-chlorostyryl)-1,3,7-trimethylxanthine (E)-1,3-Diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-3,7-dihydro-1H-purine-2,6-dione (E)-8-[2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-3,7-dihydropurine-2,6-dione 1H-Purine-2,6-dione,3,7-dihydro-1,3-diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-,(E) 8-(3-Chlorostyryl)caffeine (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione (E)-1,3,7-trimethyl-8-(3-chlorostyryl)xanthine (E)-8-(3,4-Dimethoxystyryl)-1,3-diethylxanthine 8-[(E)-2-(3-Chlorophenyl)vinyl]-1,3,7-trimethyl-3,7-dihydro-1H-pu rine-2,6-dione 8-(3-chloro-(E)-styryl)caffeine (E)-8-(3-chlorostyryl)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione

Description	(E)-8-(3-Chlorostyryl)caffeine is a selective adenosine A2A receptor antagonist. (E)-8-(3-Chlorostyryl)caffeine inhibits monoamine oxidase B (MAO-B) with a Ki value of 70 nM by a pathway that is independent of its actions on the A2A receptor. (E)-8-(3-Chlorostyryl)caffeine has the potential for Parkinson's disease research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2AR MAO-B:70 nM (Ki)
References	[1]. Nevil Vlok, et al. Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC). Bioorg Med Chem. 2006 May 15;14(10):3512-21.

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