1260092-43-0

1260092-43-0 structure

Name: Cbz-NH-PEG1-CH2COOH
Chemical Name: 2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid
CAS Number: 1260092-43-0
Molecular Formula: C₁₂H₁₅NO₅
Molecular Weight: 253.25100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-13 15:29:25
Modify Date: 2024-02-01 00:58:41
Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-(benzyloxycarbonylamino)ethoxy]acetic acid
Synonyms	z-o1pen-oh 5-(benzyloxycarbonyl-amino)-3-oxa-pentanoic acid

Description	Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.