217082-57-0

217082-57-0 structure

Name: Apelin 17
Chemical Name: Apelin-17 (human, bovine)
CAS Number: 217082-57-0
Molecular Formula: C₉₆H₁₅₆N₃₄O₂₀S
Molecular Weight: 2138.55000
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-05-17 14:02:47
Modify Date: 2024-01-10 18:56:53
Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].

Name	Apelin-17 (human, bovine)
Synonyms	h-lys-phe-arg-arg-gln-arg-pro-arg-leu-ser-his-lys-gly-pro-met-pro-phe-oh trifluoroacetate

Description	Apelin-17(human, bovine) is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) binds to human APJ receptors expressed in HEK 293 cells (pIC50=9.02). Apelin-17(human, bovine) inhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ[1][2][3].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 HIV-2
References	[1]. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun. 1998;251(2):471-476. [2]. Medhurst AD, Jennings CA, Robbins MJ, et al. Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem. 2003;84(5):1162-1172. [3]. Zou MX, et al. Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 2000;473(1):15-18.