33507-63-0

33507-63-0 structure

Name: Substance P acetate salt
Chemical Name: Substance P
CAS Number: 33507-63-0
Molecular Formula: C₆₃H₉₈N₁₈O₁₃S
Molecular Weight: 1347.630
Catalog: Biochemical Peptide
Create Date: 2018-07-16 19:06:11
Modify Date: 2024-01-02 11:01:52
Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.

Name	Substance P
Synonyms	UNII:675VGV5J1D R-Phg-S-Leu N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide Aminophenylacetylleucine L-Methioninamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- D-phenylglycyl-L-leucine H-RPKPQQFFGLM-NH2 Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 neuropeptide substance P RPKPQQFFGLM-NH2 RPKPQQFFGLM EINECS 251-545-8

Description	Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Natural Products >> Others Peptides
Target	Human Endogenous Metabolite
In Vitro	The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
References	[1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24. [2]. Zhang L, et al. MiR-34b/c-5p and the neurokinin-1 receptor regulate breast cancer cell proliferation and apoptosis. Cell Prolif. 2018 Oct 17:e12527.

Density	1.4±0.1 g/cm3
Molecular Formula	C₆₃H₉₈N₁₈O₁₃S
Molecular Weight	1347.630
Exact Mass	1346.728149
PSA	544.43000
LogP	-0.85
Index of Refraction	1.663
Storage condition	−20°C
Water Solubility	H2O: 1 mg/mL \| Soluble in water, DMSO, and Acetic Acid.

WGK Germany	3

74-87-3

98264-76-7

33507-63-0

Literature: Tetrahedron Letters, , vol. 26, # 5 p. 623 - 626

4530-20-5

13139-15-6

2488-15-5

13734-34-4

Detail

Literature: Journal of Medicinal Chemistry, , vol. 25, # 1 p. 64 - 68