GL Biochem (Shanghai) Ltd.
China
Product Name: Pyr-LYENKPRRPyIL
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: NEUROTENSIN
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Neurotensin
Price: $Inquiry/1kg
Purity: 99.0%
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Contact: Vinnie

39379-15-2

39379-15-2 structure

39379-15-2 structure

Name: Neurotensin
Chemical Name: neurotensin
CAS Number: 39379-15-2
Molecular Formula: C₇₈H₁₂₁N₂₁O₂₀
Molecular Weight: 1672.92000
Catalog: Peptides
Create Date: 2016-04-17 12:16:37
Modify Date: 2024-01-13 10:55:22
Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).

Name	neurotensin
Synonyms	NEUROTENSIN,BOVINE GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU M.W. 1672.92 C78H121N21O20 PGLU-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU PYR-LYENKPRRPYIL Neurotensin PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-TYR-ILE-LEU

Description	Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Peptides Research Areas >> Cancer
Target	Neurotensin receptors (NTR)[1]
In Vitro	Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1].
References	[1]. Wang X, et al. Curcumin inhibits neurotensin-mediated interleukin-8 production and migration of HCT116 human colon cancer cells. Clin Cancer Res. 2006 Sep 15;12(18):5346-55.

Density	1.46g/cm3
Molecular Formula	C₇₈H₁₂₁N₂₁O₂₀
Molecular Weight	1672.92000
Exact Mass	1671.91000
PSA	668.69000
LogP	4.50630
Index of Refraction	1.666
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QQ4482000

CHEMICAL NAME :: Neurotensin

CAS REGISTRY NUMBER :: 39379-15-2

LAST UPDATED :: 199304

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 500 ug/kg

SEX/DURATION :: female 4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 30,80,1992

RTECS	QQ4482000