7298-99-9

7298-99-9 structure

Name: L-Aspartic acid,3-hydroxy-, (3S)
Chemical Name: (3S)-3-hydroxy-L-aspartic acid
CAS Number: 7298-99-9
Molecular Formula: C₄H₇NO₅
Molecular Weight: 149.10
Catalog: Biochemical Amino acids and their derivatives Aspartic acid derivative
Create Date: 2018-11-30 12:31:17
Modify Date: 2026-07-02 14:48:35
L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].

Name	(3S)-3-hydroxy-L-aspartic acid
Synonyms	L-Asptic acid,3-hydroxy-, (3S) (3S)-3-hydroxy-L-aspticaci (3S)-3-hydroxy-L-asptic acid L-(-)-THREO-BETA-HYDROXYASPTIC ACID L-(-)-THREO-3-HYDROXYASPTIC ACID //BP Lthreo3Hydroxyasptic acid,L threo 3 Hydroxyasptic acid L-(-)-threo-3-Hydroxyasptic acid, EAATinhibitor/non-transportable EAAT5 inhibitor W-7 hydrochloride L-(-)-THREO-3-HYDROXYASPTIC ACID (2S,3S)-2-amino-3-hydroxybutanedioic acid threo-3-Hydroxy-L-asptic acid

Description	L-threo-3-Hydroxyaspartic acid is a potent EAAT inhibitor with Kis of 11, 19 and 14 μM for EAAT1, EAAT2 and EAAT3, respectively in HEK293 cell lines[1].
Related Catalog	Signaling Pathways >> Others >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease
Target	Ki: 11 μM (EAAT1), 14 μM (EAAT3), 19 μM (EAAT2)[1]
References	[1]. HaraR, et al Production of L-threo-3-Hydroxyaspartic Acid Using Asparaginase-DeficientEscherichia coli Expressing Asparagine Hydroxylase of Streptomyces coelicolorA3(2). Appl Environ Microbiol. 2015 Jun;81(11):3648-54 [2]. Jensen AA, Bräuner-Osborne H. Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem Pharmacol. 2004 Jun 1;67(11):2115-27.