6415-90-3

6415-90-3 structure

Name: 1Alphah,5alphah-tropan-3alpha-ol (+-)-tripate (ester), hydrobromide
Chemical Name: 1Alphah,5alphah-tropan-3alpha-ol (+-)-tripate (ester), hydrobromide
CAS Number: 6415-90-3
Molecular Formula: C₁₇H₂₄BrNO₃
Molecular Weight: 370.28100
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2016-01-31 14:42:25
Modify Date: 2024-01-06 13:00:55
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].

Name	1Alphah,5alphah-tropan-3alpha-ol (+-)-tripate (ester), hydrobromide

Description	Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	IC50: 0.39 nM (Human mAChR M4) and 0.71 nM (Chicken mAChR M4)[3]
In Vitro	Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins[4].
In Vivo	Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) hydrobromide inhibits the cardiac arrhythmia which normally occurs throughout torpor[2]. Animal Model: White-footed mice (Peromyscus sp.)[2] Dosage: 10 mg/kg Administration: Intraperitoneal injection; once, for 40 minutes Result: Increased heart rate was a decrease in cardiac arrhythmia.
References	[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. [2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. [3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. [4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8.

Molecular Formula	C₁₇H₂₄BrNO₃
Molecular Weight	370.28100
Exact Mass	369.09400
PSA	49.77000
LogP	2.82690

Precursor 0
DownStream 1
17659-49-3

1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	110901-85-4
930439-75-1	1018584-77-4
1375289-11-4	849349-65-1