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32886-15-0 11075-87-9

32886-15-0

32886-15-0 structure
32886-15-0 structure
  • Name: Lipoxamycin
  • Chemical Name: Lipoxamycin
  • CAS Number: 32886-15-0
  • Molecular Formula: C19H36N2O5
  • Molecular Weight: 372.50000
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2017-10-25 16:37:37
  • Modify Date: 2024-03-02 16:08:48
  • Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
Name Lipoxamycin
Synonyms lipoxamycin
Description Lipoxamycin is an antifungal antibiotic and a potent serine palmitoyltransferase inhibitor with an IC50 of 21 nM[1][2].
Related Catalog
Target

Serine palmitoyltransferase[1]

In Vitro Lipoxamycin has antifungal activity against a panel of humanpathogenic fungi with better potency against some of the Candida species (MIC values, 0.25-16 µg/mL). Cryptococcus neoformans is the most sensitive organism, followed by various species of Candida. Other filamentous fungi are sensitive to the Lipoxamycin in disk diffusion assays[1]. Lipoxamycin has a long alkyl chain and an amino-containing polar head group. Lipoxamycin is on the same order of potency as the sphingofungins and also have potent activity against the mammalianenzyme[1].
In Vivo Lipoxamycin is highly toxic in mice when applied subeutaneously or topically. Toxicity may be mechanism based, since studies with a Chinese hamster ovary cell mutant have shown that the serine palmitoyltransferase is an essential enzymein mammalian cells[1].
References

[1]. S M Mandala, et al. Inhibition of Serine Palmitoyl-Transferase Activity by Lipoxamycin. J Antibiot (Tokyo). 1994 Mar;47(3):376-9.

[2]. H A Whaley. The Structure of Lipoxamycin, a Novel Antifungal Antibiotic. J Am Chem Soc. 1971 Jul 28;93(15):3767-9.
Molecular Formula C19H36N2O5
Molecular Weight 372.50000
Exact Mass 372.26200
PSA 120.93000
LogP 2.91930
HS Code 2924199090
HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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