35590-86-4

35590-86-4 structure

Name: Cyclo(L-Phe-L-Val)
Chemical Name: cis-cyclo(Val-Phe)
CAS Number: 35590-86-4
Molecular Formula: C₁₄H₁₈N₂O₂
Molecular Weight: 246.30
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2016-12-27 21:33:01
Modify Date: 2025-08-26 12:11:35
Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].

Name	cis-cyclo(Val-Phe)
Synonyms	Cyclo(Val-Phe) (3S,6S)-3-isopropyl-6-benzylpiperazine-2,5-dione (3S,6S)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione cyclo(L-phenylalanyl-L-valine) (S,S)-cyclo-Val-Phe (3S,6S)-3-benzyl-6-isopropyl-2,5-piperazinedione

Description	Cyclo(L-Phe-L-Val) is a potent inhibitor of enzymes isocitrate lyase (ICL) (IC50=27 μg/mL). cyclo(L-Phe-L-Val) inhibits the gene transcription of ICL in C. albicans under C2-carbon-utilizing conditions[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
Target	Isocitrate lyase (ICL)[1]
In Vitro	Cyclo(L-Phe-L-Val) (32 μg/mL; 2 d) 分别降低白色念珠菌 SC5314 (野生型)、MRC10 (Δicl) 和 MRC11 (Δicl + ICL) 中的 icl 产物水平[1]。
References	[1]. Kim H, et al. Inhibitory Effects of Diketopiperazines from Marine-Derived Streptomyces puniceus on the Isocitrate Lyase of Candida albicans. Molecules. 2019 Jun 4;24(11):2111.