87468-58-4

87468-58-4 structure

Name: Biotin-Substance P
Chemical Name: Biotin-Substance P,Biotin-RPKPQQFFGLM-NH2
CAS Number: 87468-58-4
Molecular Formula: C₇₃H₁₁₂N₂₀O₁₅S₂
Molecular Weight: 1573.93000
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2019-01-12 19:14:55
Modify Date: 2024-01-14 18:25:14
Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

Name	Biotin-Substance P,Biotin-RPKPQQFFGLM-NH2
Synonyms	Substance p,N2-(5-(hexahydro-2-oxo-1H-thieno(3,4-D)imidazol-4-yl)-1-oxopentyl)-,(3as-(3aalpha,4beta,6aalpha)) BIOTINYL-SUBSTANCE P BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 Abasp BIOTIN-SUBSTANCE P BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 BIOTIN-RPKPQQFFGLM-NH2

Description	Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
References	[1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.