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87468-58-4

87468-58-4 structure
87468-58-4 structure
  • Name: Biotin-Substance P
  • Chemical Name: Biotin-Substance P,Biotin-RPKPQQFFGLM-NH2
  • CAS Number: 87468-58-4
  • Molecular Formula: C73H112N20O15S2
  • Molecular Weight: 1573.93000
  • Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
  • Create Date: 2019-01-12 19:14:55
  • Modify Date: 2024-01-14 18:25:14
  • Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].

Name Biotin-Substance P,Biotin-RPKPQQFFGLM-NH2
Synonyms Substance p,N2-(5-(hexahydro-2-oxo-1H-thieno(3,4-D)imidazol-4-yl)-1-oxopentyl)-,(3as-(3aalpha,4beta,6aalpha))
BIOTINYL-SUBSTANCE P
BIOTINYL-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
Abasp
BIOTIN-SUBSTANCE P
BIOTIN-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
BIOTIN-RPKPQQFFGLM-NH2
Description Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R)[1].
Related Catalog
In Vitro The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].
References

[1]. Grady EF, et al. Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor. Mol Biol Cell. 1995 May;6(5):509-24.

Molecular Formula C73H112N20O15S2
Molecular Weight 1573.93000
Exact Mass 1572.81000
PSA 611.44000
LogP 5.42560
Storage condition -20°C