Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: proglumide(6620-60-6)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

6620-60-6

6620-60-6 structure

6620-60-6 structure

Name: Proglumide
Chemical Name: proglumide
CAS Number: 6620-60-6
Molecular Formula: C₁₈H₂₆N₂O₄
Molecular Weight: 334.410
Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
Create Date: 2018-04-07 08:00:00
Modify Date: 2026-07-07 20:00:22
Proglumide is a known cholecystokinin (CCK) antagonist.

Name	proglumide
Synonyms	dl-4-benzamido-n,n-dipropylglutamicacid 4-benzamido-N,N-dipropyl-DL-glutamic acid Diethylaminosulfur trifluoride 38-0 NSC9416 PROGLUMIDE SELECTIVE CHOLECYSTOK N-Benzoyl-N,N-dipropyl-α-glutamine DL-4-Benzamido-N,N-dipropylglutaramic Acid 4-(Benzoylamino)-5-(dipropylamino)-5-oxopentanoic acid 4-BenzaMido-5-(dipropylaMino)-5-oxopentanoic acid Glutamic acid, 4-benzamido-N,N-dipropyl-, DL- (8CI) promide(pasympatholytic) (±)-proglumide ulcutin milide kxm Proglumide - Bio-X Milid Milide Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo- (9CI) Xylamide(gastroprotectite agent) (+/-)-4-benzamido-n,n-dipropylglutamic acid midelid N-(Phenylcarbonyl)-N,N-dipropyl-α-glutamin N-benzoyl-N',N'-dipropyl-RS-isoglutamine Proglumide (jp15/usan/inn) EINECS 229-567-4 binoside Midelid PROGLUMIDE N-Benzoyl-N′,N′-dipropyl-DL-isoglutamine Nulsa (tn) Binoside LABOTEST-BB LT00772215 D01818 N-Benzoyl-N',N'-di-n-propyl-DL-isoglutamine (4R)-4-benzamido-5-(dipropylamino)-5-oxopentanoic acid ProM cr242 Xyde (RS)-proglumide PROGUMIDE gastrotopic N-Benzoyl-N',N'-dipropyl-DL-isoglutamine nulsa w5219 Gastrotopic MFCD00055071 milid DL-Proglumide 4-(BenzoylaMino)-5-(dipropylaMino)-5-oxo-pentanoic Acid Factory Supply Bulk Price Proglumide CAS6-6with High Quality in Stock 242dl 4-benzamido-5-(dipropylamino)-5-oxopentanoic acid Proglumide //BP xylamide(gastroprotectiveagent) NSC-9416 Promid xylamide N-(Phenylcarbonyl)-N,N-dipropyl-α-glutamine N(2)-benzoyl-N,N-dipropyl-alpha-glutamine Nulsa Pentanoic acid, 4-(benzoylamino)-5-(dipropylamino)-5-oxo-, (+-) Ulcutin proglumide(6-6) (+-)-pentanoicaci n-dipropyl-4-benzamido-dl-glutamicaci xyde Proglumide, 10 mM in DMSO Xylamide

Description	Proglumide is a known cholecystokinin (CCK) antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Cancer
Target	CCK[1]
References	[1]. Ahmad M, et al. The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus.

Density	1.1±0.1 g/cm3
Boiling Point	589.8±45.0 °C at 760 mmHg
Melting Point	148.5--152ºC
Molecular Formula	C₁₈H₂₆N₂O₄
Molecular Weight	334.410
Flash Point	310.5±28.7 °C
Exact Mass	334.189270
PSA	86.71000
LogP	2.53
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.534

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MA2805000

CHEMICAL NAME :: Glutaramic acid, 4-benzamido-N,N-dipropyl-, DL-

CAS REGISTRY NUMBER :: 6620-60-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C18-H26-N2-O4

MOLECULAR WEIGHT :: 334.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5190 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Endocrine - other changes Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 58,3653,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 20,447,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5190 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Endocrine - other changes Skin and Appendages - corrosive (after topical exposure)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MIMEAO Minerva Medica. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1909- Volume(issue)/page/year: 58,3653,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 69 gm/kg/30D-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 546 gm/kg/26W-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in pituitary weight Blood - changes in leukocyte (WBC) count

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 327600 mg/kg/26W-C

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,203,1971 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1350 mg/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,225,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5400 mg/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 5,225,1971

HS Code	2924299090

91569-94-7 structure

91569-94-7

142-84-7 structure

142-84-7

~0%

6620-60-6 structure

6620-60-6

102743-01-1 structure

102743-01-1

Literature: European Journal of Medicinal Chemistry, , vol. 21, # 1 p. 9 - 20

Precursor 1
142-84-7
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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