Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Prothipendyl
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Purity: 98.0%
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303-69-5

303-69-5 structure

Name: Prothipendyl
Chemical Name: N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine
CAS Number: 303-69-5
Molecular Formula: C₁₆H₁₉N₃S
Molecular Weight: 285.40700
Create Date: 2018-04-19 08:00:00
Modify Date: 2025-08-25 13:22:45

Name	N,N-dimethyl-3-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-1-amine
Synonyms	Prothipendyl Prothipendylum [INN-Latin] Prothipendyl [INN:BAN] LG 206 Largophren Protipendilo [INN-Spanish] (3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin Tumovan Timoval (3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine Timovan Dominal 10-<3-Dimethylamino-propyl>-4-aza-phenothiazin

Density	1.168g/cm3
Boiling Point	430.8ºC at 760mmHg
Molecular Formula	C₁₆H₁₉N₃S
Molecular Weight	285.40700
Flash Point	214.3ºC
Exact Mass	285.13000
PSA	44.67000
LogP	3.70100
Index of Refraction	1.621

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8576000

CHEMICAL NAME :: 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-69-5

BEILSTEIN REFERENCE NO. :: 0259865

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C16-H19-N3-S

MOLECULAR WEIGHT :: 285.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 18,373,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 415 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - antipsychotic

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,374,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3040 mg/kg/22W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

HS Code	2934999090

261-96-1

109-54-6

303-69-5

Literature: Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

95873-97-5

303-69-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

92316-06-8

303-69-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

91902-18-0

303-69-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

137-07-5

303-69-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

6631-37-4

303-69-5

Literature: Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

124-40-3

109-70-6

303-69-5

Literature: DEGUSSA Patent: DE1014544 , 1956 ;

Precursor 8
261-96-1 109-54-6 92316-06-8 91902-18-0
137-07-5 6631-37-4 124-40-3 109-70-6
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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