Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Metiapine
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Purity: 98.0%
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5800-19-1

5800-19-1 structure

5800-19-1 structure

Name: Metiapine
Chemical Name: 8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
CAS Number: 5800-19-1
Molecular Formula: C₁₉H₂₁N₃S
Molecular Weight: 323.45500
Create Date: 2018-02-28 08:00:00
Modify Date: 2024-01-14 13:35:47

Name	8-methyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzothiazepine
Synonyms	11-(N-Methylpiperazino)-2-methyldibenzo<b.f>-1,4-thiazepin 2-methyl-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine DIBENZO(b,f)(1,4)THIAZEPINE,2-METHYL-11-(4-METHYL-1-PIPERAZINYL) Metiapine Metiapina Metiapina [INN-Spanish] Metiapinum 3-Methyl-11-(4-methyl-1-piperazinyl)dibenzo<b,f><1,4>thiazepin Metiapinum [INN-Latin] 2-Methyl-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine

Density	1.22g/cm3
Boiling Point	473.6ºC at 760mmHg
Molecular Formula	C₁₉H₂₁N₃S
Molecular Weight	323.45500
Flash Point	240.2ºC
Exact Mass	323.14600
PSA	44.14000
LogP	3.09670
Index of Refraction	1.669

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HQ2275000

CHEMICAL NAME :: Dibenzo(b,f)(1,4)thiazepine, 2-methyl-11-(4-methyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 5800-19-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H21-N3-S

MOLECULAR WEIGHT :: 323.49

WISWESSER LINE NOTATION :: T C676 BS INJ M1 J- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 934 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,334,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 487 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,220,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 22,334,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,220,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 42 mg/kg

SEX/DURATION :: female 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,212,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 24 mg/kg

SEX/DURATION :: female 9-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 25,212,1973

3159-10-2 structure

3159-10-2

~%

5800-19-1 structure

5800-19-1

Literature: Schmutz,J. et al. Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

109-01-3 structure

109-01-3

13745-90-9 structure

13745-90-9

~%

5800-19-1 structure

5800-19-1

Literature: Schmutz,J. et al. Helvetica Chimica Acta, 1967 , vol. 50, p. 245 - 254

Precursor 2
3159-10-2 109-01-3
DownStream 0