CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TX7955000
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CHEMICAL NAME :
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1,2-Propanediamine, N(sup 1),N(sup 1)-dimethyl-N(sup 2)-(1-nitro-9-acridinyl)-, dihydrochloride
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CAS REGISTRY NUMBER :
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65094-73-7
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LAST UPDATED :
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198910
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C18-H20-N4-O2.2Cl-H
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MOLECULAR WEIGHT :
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397.34
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WISWESSER LINE NOTATION :
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T C666 BNJ GNW IMY1&1N1&1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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105 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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13300 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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99200 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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21300 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Bird - pigeon
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DOSE/DURATION :
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21 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Human Lymphocyte
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DOSE/DURATION :
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80 nmol/L/69H
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,93,1979
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