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103884-98-6

103884-98-6 structure
103884-98-6 structure
  • Name: 2'-Deoxy-2'-fluoroguanosine
  • Chemical Name: 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • CAS Number: 103884-98-6
  • Molecular Formula: C10H12FN5O4
  • Molecular Weight: 285.23
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
  • Create Date: 2018-09-05 18:17:57
  • Modify Date: 2024-01-04 09:48:28
  • 2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Name 2-amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonyms 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-
2-Amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one
2'-Deoxy-2'-fluoroguanosine
Guanosine, 2'-deoxy-2'-fluoro-
Description 2-Amino-9-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-6H-purin-6-one (9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 2.2±0.1 g/cm3
Boiling Point 726.1ºC
Molecular Formula C10H12FN5O4
Molecular Weight 285.23
Flash Point 392.9ºC
Exact Mass 285.087341
PSA 139.28000
LogP -0.53
Vapour Pressure 3.94E-22mmHg at 25°C
Index of Refraction 1.876

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0789000
CHEMICAL NAME :
6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)- 1,9-dihydro-
CAS REGISTRY NUMBER :
103884-98-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H12-F-N5-O4
MOLECULAR WEIGHT :
285.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
50 umol/L
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 29,2389,1986

Chemsrc provides CAS#:103884-98-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 103884-98-6 | Chemsrc address: https://m.chemsrc.com/en/baike/345781.html

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