14365-45-8

14365-45-8 structure

Name: 9-(2-Deoxy-β-L-Ribofuranosyl)Adenine
Chemical Name: 2'-Deoxy-L-adenosine
CAS Number: 14365-45-8
Molecular Formula: C₁₀H₁₃N₅O₃
Molecular Weight: 251.24200
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2018-06-08 17:03:52
Modify Date: 2024-01-13 18:56:13
2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].

Name	2'-Deoxy-L-adenosine
Synonyms	2'-desoxyadenosine 2'-Desoxy-adenosin 2'-deoxy-adenosine

Description	2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV
In Vitro	2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].
In Vivo	2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].

HS Code	2934999090

Precursor 4
339091-23-5 233681-08-8 216571-43-6 4005-49-6
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%