475085-57-5
475085-57-5 structure
- Name: MRE-269
- Chemical Name: {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid
- CAS Number: 475085-57-5
- Molecular Formula: C25H29N3O3
- Molecular Weight: 419.516
- Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
- Create Date: 2018-09-18 12:24:44
- Modify Date: 2025-08-20 10:10:18
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MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
| Name | {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid |
|---|---|
| Synonyms |
Acetic acid, 2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-
MRE-269 2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID 2-(4-{[(3,5-dichlorophenyl)carbamoyl]amino}phenoxy)-2-methylpropanoic acid {4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid 4-(3,5-dichlorophenylureido)phenoxyisobutyric acid {4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid ACT-333679 2-<4<<<(3,5-dichlorophenyl)amino>carbonyl>amino>phenoxy>-2-methylpropionic acid 2-{4-[N'-(3,5-dichlorophenyl)ureido]phenoxy}isobutyric acid 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid Propanoic acid,2-[4-[[[(3,5-dichlorophenyl)amino]carbonyl]amino]phenoxy]-2-methyl |
| Description | MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist. |
|---|---|
| Related Catalog | |
| Target |
IP Receptor |
| In Vitro | MRE-269 induces endothelium-independent vasodilation of rat extralobar pulmonary artery (EPA). MRE-269 or other IP receptor agonists including epoprostenol, iloprost, treprostinil and beraprost increase cAMP levels in hPASMC[1]. MRE-269 induces concentration-dependent vasodilation in LPA(+), LPA(-), and SPA(-)[3]. |
| In Vivo | The vasorelaxant effects of MRE-269 on rat small intralobar pulmonary artery (SIPA) and EPA are the same, while the other IP receptor agonists induce less vasodilation in SIPA than in EPA[1]. MRE-269 produces substantial relaxation of rat small pulmonary artery, although its effects are only significant at high concentrations of above 10 μM (pEC50, 4.98±0.22). By contrast, in rat small pulmonary veins, MRE-269 only produces minimal relaxation over the whole concentration range, with only significant relaxation occurring at the two highest doses of MRE-269 of 10 and 100 μM[2]. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.1±55.0 °C at 760 mmHg |
| Molecular Formula | C25H29N3O3 |
| Molecular Weight | 419.516 |
| Flash Point | 318.0±31.5 °C |
| Exact Mass | 419.220886 |
| PSA | 75.55000 |
| LogP | 5.09 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.588 |
| Storage condition | 2-8℃ |
|
~%
475085-57-5 |
| Literature: Asaki, Tetsuo; Hamamoto, Taisuke; Sugiyama, Yukiteru; Kuwano, Keiichi; Kuwabara, Kenji Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 21 p. 6692 - 6704 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |