926922-29-4

926922-29-4 structure

Name: AP 24149
Chemical Name: 9-[(E)-2-(2,6-Dimethylphenyl)vinyl]-N-[4-(dimethylphosphoryl)phen yl]-9H-purin-6-amine
CAS Number: 926922-29-4
Molecular Formula: C₂₃H₂₄N₅OP
Molecular Weight: 417.44300
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
Create Date: 2017-04-21 18:13:42
Modify Date: 2024-09-08 07:48:31
AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

Name	9-[(E)-2-(2,6-Dimethylphenyl)vinyl]-N-[4-(dimethylphosphoryl)phen yl]-9H-purin-6-amine

Description	AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl
Target	Abl:3.6 nM (IC50) Src:9.1 nM (IC50)
References	[1]. Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28.

Molecular Formula	C₂₃H₂₄N₅OP
Molecular Weight	417.44300
Exact Mass	417.17200
PSA	82.51000
LogP	5.13560

926922-15-8

926922-29-4

Literature: Wang, Yihan; Shakespeare, William C.; Huang, Wei-Sheng; Sundaramoorthi, Raji; Lentini, Scott; Das, Sasmita; Liu, Shuangying; Banda, Geeta; Wen, David; Zhu, Xiaotian; Xu, Qihong; Keats, Jeffrey; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T.; Broudy, Mark I.; Russian, Karin; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4907 - 4912

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