926922-29-4
926922-29-4 structure
- Name: AP 24149
- Chemical Name: 9-[(E)-2-(2,6-Dimethylphenyl)vinyl]-N-[4-(dimethylphosphoryl)phen yl]-9H-purin-6-amine
- CAS Number: 926922-29-4
- Molecular Formula: C23H24N5OP
- Molecular Weight: 417.44300
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Bcr-Abl
- Create Date: 2017-04-21 18:13:42
- Modify Date: 2025-09-17 20:59:31
-
AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].
| Name | 9-[(E)-2-(2,6-Dimethylphenyl)vinyl]-N-[4-(dimethylphosphoryl)phen yl]-9H-purin-6-amine |
|---|
| Description | AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Abl:3.6 nM (IC50) Src:9.1 nM (IC50) |
| References |
| Molecular Formula | C23H24N5OP |
|---|---|
| Molecular Weight | 417.44300 |
| Exact Mass | 417.17200 |
| PSA | 82.51000 |
| LogP | 5.13560 |
|
~%
926922-29-4 |
| Literature: Wang, Yihan; Shakespeare, William C.; Huang, Wei-Sheng; Sundaramoorthi, Raji; Lentini, Scott; Das, Sasmita; Liu, Shuangying; Banda, Geeta; Wen, David; Zhu, Xiaotian; Xu, Qihong; Keats, Jeffrey; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T.; Broudy, Mark I.; Russian, Karin; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 17 p. 4907 - 4912 |
