490-59-5
490-59-5 structure
- Name: Alloxazine;Isoalloxazine
- Chemical Name: alloxazine
- CAS Number: 490-59-5
- Molecular Formula: C10H6N4O2
- Molecular Weight: 214.18000
- Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
- Create Date: 2018-03-31 08:00:00
- Modify Date: 2025-08-25 18:29:53
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Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2].
| Name | alloxazine |
|---|---|
| Synonyms |
Alloxazin
1H-benzo[g]pteridine-2,4-dione Alloxazine |
| Description | Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5’N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 2.9 μM (AMP)[1] |
| In Vitro | Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1]. Cell Viability Assay[1] Cell Line: PGT-β cells Concentration: 0-30 μM Incubation Time: 20 min Result: Inhibited the cyclic AMP generation concentration-dependently with an IC IC50 of 2.9 μM. |
| In Vivo | Alloxazine (1 µmol/L, 0-20 min) suppresses NECA-induced vasodilation[2]. Animal Model: 250–320 g male Sprague-Dawley rats[2] Dosage: 1 µmol/L Administration: Cortical surface suffusion; 1 µmol/L once Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L. |
| References |
| Density | 1.509g/cm3 |
|---|---|
| Molecular Formula | C10H6N4O2 |
| Molecular Weight | 214.18000 |
| Exact Mass | 214.04900 |
| PSA | 91.50000 |
| LogP | 0.15960 |
| Index of Refraction | 1.699 |
| Storage condition | -20℃ |
| WGK Germany | 3 |
|---|---|
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |