63721-06-2

63721-06-2 structure

Name: NH-bis-PEG5
Chemical Name: 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
CAS Number: 63721-06-2
Molecular Formula: C₂₀H₄₃NO₁₀
Molecular Weight: 457.55600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-09-26 12:31:02
Modify Date: 2024-01-09 15:37:25
NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Synonyms	3,6,9,12,18,21,24,27-Octaoxa-15-azanonacosane-1,29-diol

Description	NH-bis-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562