Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Monactin
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Monactin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
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7182-54-9

7182-54-9 structure

7182-54-9 structure

Name: Monactin
Chemical Name: Monactin
CAS Number: 7182-54-9
Molecular Formula: C₄₁H₆₆O₁₂
Molecular Weight: 750.95600
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-08-23 23:53:39
Modify Date: 2025-08-25 19:14:42
Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

Name	Monactin
Synonyms	Nonactin,5-demethyl-5-ethyl 5-ethyl-2,11,14,20,23,29,32-heptamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone Akd-1B

Description	Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3]. Monactin inhibits TCF/β-catenin transcriptional activity[4]. At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].
In Vivo	Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].
References	[1]. Graven SN, et al. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966;5(5):1735-1742. [2]. Murer H, et al. On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem. 1975;250(18):7392-7396. [3]. Harinantenaina Rakotondraibe L, et al. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015;25(23):5646-5649. [4]. Tamai, Y, et al. Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84(2), 1245-1250. [5]. Harold FM, et al. Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cells. J Bacteriol. 1968;95(3):816-823.

Density	1.035g/cm3
Boiling Point	896.9ºC at 760 mmHg
Molecular Formula	C₄₁H₆₆O₁₂
Molecular Weight	750.95600
Flash Point	353.8ºC
Exact Mass	750.45500
PSA	142.12000
LogP	6.41210
Index of Refraction	1.451

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