185391-33-7

185391-33-7 structure

Name: TCS 1105
Chemical Name: N-(4-Fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide
CAS Number: 185391-33-7
Molecular Formula: C₁₇H₁₃FN₂O₂
Molecular Weight: 296.29600
Catalog: Research Areas Neurological Disease
Create Date: 2016-03-23 17:47:55
Modify Date: 2024-01-14 14:37:48
TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].

Name	N-(4-Fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide

Description	TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. [2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812.