213819-48-8

213819-48-8 structure

Name: Belotecan hydrochloride(CKD-602)
Chemical Name: Belotecan hydrochloride
CAS Number: 213819-48-8
Molecular Formula: C₂₅H₂₈ClN₃O₄
Molecular Weight: 469.96100
Catalog: Research Areas Cancer
Create Date: 2018-07-20 11:18:54
Modify Date: 2024-01-03 18:51:03
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative.

Name	Belotecan hydrochloride
Synonyms	Belotecan HCl Camtobell hydrochloride CKD 602 Belotecan (hydrochloride)

Description	Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic and water-soluble camptothecin derivative.
Related Catalog	Research Areas >> Cancer
Target	Top1
In Vitro	Belotecan exerts a significant cytotoxic effect on YD-8, YD-9 and YD-38 cells in a time- and dose-dependent manner with IC50 values of 2.4, 0.18 and 0.05 μg/mL at 72 h following treatment. Belotecan induces apoptosis in these cell lines. Belotecan induces G2/M phase arrest in oral squamous cell cancer cells[1]. Belotecan shows a significant anticancer effect on glioma cells, with IC50 values of 9.07 nM for LN229, 14.57 nM for U251 MG, 29.13 nM for U343 MG, and 84.66 nM for U87 MG[2].
In Vivo	Belotecan has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group[3].
Cell Assay	The cells are treated with different concentrations (0.01, 0.1, 0.5, 1, 5 and 10 μg/mL) of belotecan for 24, 48 and 72 h. Control samples of each cell line are treated with medium only. Cell viability is measured using the MTS assay[1].
Animal Admin	Mice: Nude mice with established U87MG glioma are treated with a dose of belotecan of 0 mg/kg (control group, injection with saline), 40 mg/kg (group A) or 60 mg/kg (group B). Thereafter, the dose is repeated once every 4 days for a total of four doses. Tumor volume is measured histologically and apoptosis is detected[1].
References	[1]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell®) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142. [2]. Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9. [3]. Kim CY, et al. Antitumor activity of CKD-602, a camptothecin derivative, in a mouse glioma model. J Clin Neurosci. 2012 Feb;19(2):301-5.

Boiling Point	772.4ºC at 760mmHg
Molecular Formula	C₂₅H₂₈ClN₃O₄
Molecular Weight	469.96100
Flash Point	420.9ºC
Exact Mass	469.17700
PSA	93.45000
LogP	3.81300
Vapour Pressure	4.21E-25mmHg at 25°C
Storage condition	2-8℃

78287-26-0

75-31-0

77-78-1

~46%

213819-48-8

Literature: Ahn, Soon Kil; Choi, Nam Song; Jeong, Byeong Seon; Kim, Kye Kwang; Journ, Duck Jin; Kim, Joon Kyum; Lee, Sang Joon; Kim, Jung Woo; Hong, Chung Il; Jew, Sang-sup Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1141 - 1144

7689-03-4

213819-48-8

Literature: Journal of Heterocyclic Chemistry, , vol. 37, # 5 p. 1141 - 1144

Precursor 4
78287-26-0 75-31-0 77-78-1 7689-03-4
DownStream 0

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