265646-85-3

265646-85-3 structure

Name: Endovion
Chemical Name: 1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-tetrazol-5-yl)phenyl]urea
CAS Number: 265646-85-3
Molecular Formula: C₁₆H₉BrF₆N₆O
Molecular Weight: 495.18
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2016-12-15 22:33:43
Modify Date: 2026-07-16 11:51:22
Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].

Name	1-[3,5-bis(trifluoromethyl)phenyl]-3-[5-bromo-2-(2H-tetrazol-5-yl)phenyl]urea
Synonyms	NS3728 >= (HPLC) Urea,N-(3,5-bis(trifluoromethyl)phenyl)-N'-(4-bromo-2-(1H-tetrazol-5-yl)phenyl) Endovion, 10 mM in DMSO Cl Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728 NS 3728 UNII-943YH53W21 Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl] NS3728 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea

Description	Endovion (NS3728) is a pharmacological anion channel inhibitor (like chloride channel) and the specific VRAC/VSOAC blocker. Endovion (NS3728) is also an Anoctamin-1 (ANO 1) channel inhibitor[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Others
Target	Chloride channel, VRAC/VSOAC[1]. ANO1[2].
References	[1]. Sørensen BH, et al. Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C857-73. [2]. Sauter DR, et al. ANO1 (TMEM16A) in pancreatic ductal adenocarcinoma (PDAC). Pflugers Arch. 2015 Jul;467(7):1495-1508.