945212-59-9

945212-59-9 structure

Name: Macimorelin acetate
Chemical Name: acetic acid,2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
CAS Number: 945212-59-9
Molecular Formula: C₂₈H₃₄N₆O₅
Molecular Weight: 534.60700
Catalog: Signaling Pathways GPCR/G Protein GHSR
Create Date: 2016-07-26 03:53:36
Modify Date: 2024-01-10 16:22:26
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].

Name	acetic acid,2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide
Synonyms	Macimorelin acetate UNII-AQZ1003RMG EP 1572 acetate AEZS-130 ARD 07 acetate

Description	Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS)[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Endocrinology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> GHSR
Target	GHSR[1]
In Vivo	Macimorelin 醋酸酯 (5mg/kg，每日两次，连续 2 周) 可降低 IHKA 小鼠模型的癫痫发作次数和持续时间[2]。 Animal Model: Intrahippocampal kainic acid (IHKA) mouse model[2] Dosage: 5 mg/kg Administration: Intraperitoneal injection (i.p.), twice daily for 2 weeks. Result: Significantly decreased the number and duration of seizures during the treatment period, but had no antiepileptogenic or disease-modifying effect.
References	[1]. Jose M Garcia, et al. Macimorelin as a Diagnostic Test for Adult GH Deficiency. J Clin Endocrinol Metab. 2018 Aug 1;103(8):3083-3093. [2]. An Buckinx, et al. Translational potential of the ghrelin receptor agonist macimorelin for seizure suppression in pharmacoresistant epilepsy. Eur J Neurol. 2021 Sep;28(9):3100-3112. [3]. Ali SA, Garcia JM. Randomized clinical trial of the novel oral ghrelin mimetic macimorelin in the treatment of cancer cachexia: study design and preliminary results. Endocr Rev. 2013;34: