63264-29-9

63264-29-9 structure

Name: N2-ibu-2'-OMe-rG
Chemical Name: N2-isobutyryl-2'-O-methyl guanosine
CAS Number: 63264-29-9
Molecular Formula: C₁₅H₂₁N₅O₆
Molecular Weight: 367.36
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-07-23 12:08:04
Modify Date: 2024-01-09 22:03:16
N2-Isobutyryl-2'-O-methylguanosine (N2-IBU-2'-OME-RG) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	N2-isobutyryl-2'-O-methyl guanosine
Synonyms	N2-isobutyryl-2'-O-methylguanosine IBU-2'-OME-G 2'-O-methyl-N2-isobutyrylguanosine N2-isobutyryl-O2'-methyl-guanosine N2-ibu-2'-OMe-rG

Description	N2-Isobutyryl-2'-O-methylguanosine (N2-IBU-2'-OME-RG) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

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63264-29-9

Literature: Zlatev, Ivan; Vasseur, Jean-Jacques; Morvan, Francois Tetrahedron, 2007 , vol. 63, # 45 p. 11174 - 11178