60117-35-3
60117-35-3 structure
- Name: ANB-NOS
- Chemical Name: 5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester
- CAS Number: 60117-35-3
- Molecular Formula: C11H7N5O6
- Molecular Weight: 305.203
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-24 18:54:38
- Modify Date: 2024-01-09 06:26:06
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ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | 5-Azido-2-nitrobenzoic acid N-hydroxysuccinimide ester |
|---|---|
| Synonyms |
1-[(5-Azido-2-nitrobenzoyl)oxy]-2,5-pyrrolidinedione
2,5-Pyrrolidinedione, 1-[(5-azido-2-nitrobenzoyl)oxy]- 2,5-Pyrrolidinedione, 1-((5-azido-2-nitrobenzoyl)oxy)- (2,5-dioxopyrrolidin-1-yl) 5-azido-2-nitrobenzoate |
| Description | ANB-NOS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Melting Point | 131-133ºC |
|---|---|
| Molecular Formula | C11H7N5O6 |
| Molecular Weight | 305.203 |
| Exact Mass | 305.039642 |
| PSA | 159.25000 |
| LogP | 0.53 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
|
~%
60117-35-3 |
| Literature: Bernardi, Dan; Ba, Lalla Aicha; Kirsch, Gilbert Synthesis, 2007 , # 1 p. 140 - 144 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |