6054-98-4
6054-98-4 structure
- Name: Olsalazine (Disodium)
- Chemical Name: olsalazine sodium
- CAS Number: 6054-98-4
- Molecular Formula: C14H8N2Na2O6
- Molecular Weight: 346.203
- Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
- Create Date: 2018-06-13 15:52:16
- Modify Date: 2024-01-02 18:15:30
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Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate.
| Name | olsalazine sodium |
|---|---|
| Synonyms |
Azodisal sodium
3,3'-(E)-diazène-1,2-diylbis(6-hydroxybenzoate) de disodium Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt Benzoic acid, 3,3'-[(E)-1,2-diazenediyl]bis[6-hydroxy-, sodium salt (1:2) Olsalazine Sodium Salt Dipentum EINECS 227-975-7 Disodium 3,3'-[(E)-1,2-diazenediyl]bis(6-hydroxybenzoate) Olsalazine disodium Dinatrium-3,3'-(E)-diazen-1,2-diylbis(6-hydroxybenzolcarboxylat) Disodium 3,3'-(E)-diazene-1,2-diylbis(6-hydroxybenzoate) MFCD00013300 Olsalazine (Disodium) |
| Description | Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate. |
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| Related Catalog | |
| References |
| Boiling Point | 557.9ºC at 760 mmHg |
|---|---|
| Melting Point | 240ºC |
| Molecular Formula | C14H8N2Na2O6 |
| Molecular Weight | 346.203 |
| Flash Point | 291.2ºC |
| Exact Mass | 346.017761 |
| PSA | 145.44000 |
| LogP | 0.24020 |
| Storage condition | -20°C Freezer |
| HS Code | 2928000090 |
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| HS Code | 2928000090 |
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| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |