6054-98-4
6054-98-4 structure
- Name: Olsalazine (Disodium)
- Chemical Name: olsalazine sodium
- CAS Number: 6054-98-4
- Molecular Formula: C14H8N2Na2O6
- Molecular Weight: 346.203
- Catalog: API Digestive system medication Acid and gastric mucosal protective drugs
- Create Date: 2018-06-13 15:52:16
- Modify Date: 2026-07-01 19:15:24
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Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate.
| Name | olsalazine sodium |
|---|---|
| Synonyms |
Osazaline
Benzoicacid,3,3’-azobis[6-hydroxy-,disodiumsalt 3,3'-(E)-diazène-1,2-diylbis(6-hydroxybenzoate) de disodium 3,3’-azobis[6-hydroxy-benzoicacidisodiumsalt Olsalazine Sodium Salt Acid mordant Yellow 5 5,5′-Azobis(salicylic acid, sodium salt) Mordant yellow 5 sodium salt olsalazinedisodiumsalt disodium 5,5'-azodisalicylate Olsalazine sodium for performance test (O0146010) Olsalazine sodium //BP Azodisal sodium Olsalazine sodium for performance test CRS Olsalazine Sodium (CJ-91B) Benzoic acid, 3,3'-[(E)-1,2-diazenediyl]bis[6-hydroxy-, sodium salt (1:2) 4,4′-Dihydroxyazobenzene-3,3′-dicboxylic acid disodium salt Mordant Yellow 5 Dipentum 3,3'-azobis(6-hydroxy-benzoic acid) disodium salt Sodium 5,5'-(diazene-1,2-diyl)bis(2-hydroxybenzoate) Disodium 5,5'-(Diazene-1,2-diyl)bis(2-hydroxybenzoate) Disodium 3,3'-[(E)-1,2-diazenediyl]bis(6-hydroxybenzoate) 5,5'-Azobis(2-hydroxybenzoic acid sodium) salt OLSALAZINE DISODIUM C.I Azodisal Sodium OLSALAZINE SODIUM Olsalazine sodium, >= 3,3Azobis(6-hydroxybenzoic Acid) Sodium Salt Chrome Yellow AS Olsalazine sodium CRS Disodium Azodisalicylate Olsalazine disodium Olsalazine disodium, 10 mM in DMSO MFCD00013300 Benzoic acid, 3,3-(1,2-diazenediyl)bis[6-hydroxy-, sodium salt (1:2) Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt C.I.Mordant Yellow 5:C.I CJ-91B EINECS 227-975-7 5,5'-Azobissalicylic acid disodium salt Dinatrium-3,3'-(E)-diazen-1,2-diylbis(6-hydroxybenzolcarboxylat) Disodium 3,3'-(E)-diazene-1,2-diylbis(6-hydroxybenzoate) |
| Description | Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate. |
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| Related Catalog | |
| References |
| Boiling Point | 557.9ºC at 760 mmHg |
|---|---|
| Melting Point | 240ºC |
| Molecular Formula | C14H8N2Na2O6 |
| Molecular Weight | 346.203 |
| Flash Point | 291.2ºC |
| Exact Mass | 346.017761 |
| PSA | 145.44000 |
| LogP | 0.24020 |
| Storage condition | -20°C Freezer |
| HS Code | 2928000090 |
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| HS Code | 2928000090 |
|---|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |