61574-54-7

61574-54-7 structure

Name: Pregnenolone-d4-1
Chemical Name: pregnenolone-17alpha,21,21,21-d4
CAS Number: 61574-54-7
Molecular Formula: C₂₁H₂₈D₄O₂
Molecular Weight: 320.50200
Create Date: 2018-05-16 08:00:00
Modify Date: 2024-01-03 18:29:49
Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].

Name	pregnenolone-17alpha,21,21,21-d4
Synonyms	1,2:4,5-di-O-cyclohexylidene inositol 1,2:4,5-Biscyclohexylidene DL-myo-Inositol 1,2:4,5-Di-O-cyclohexylidene-D,L-myo-inositol 1,2:4,5-dicyclohexylidene-myo-inositol 1,2:4,5-di-O,O-cyclohexylidene-myo-inositol 17,21,21,21-d4-pregnenolone

Description	Pregnenolone-d4-1 (3β-Hydroxy-5-pregnen-20-one-d4-1) is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [3]. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. [4]. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7.

Molecular Formula	C₂₁H₂₈D₄O₂
Molecular Weight	320.50200
Exact Mass	320.26500
PSA	37.30000
LogP	4.51530

Precursor 0
DownStream 2
1112-02-3 53-43-0

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