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79514-49-1

79514-49-1 structure
79514-49-1 structure
  • Name: Hydrazinecarboselenoamide,N,N-dimethyl-2-[1-(2-pyridinyl)ethylidene]-
  • Chemical Name: 1-λ1-selanyl-N,N-dimethyl-N'-[(E)-1-pyridin-2-ylethylideneamino]methanimidamide
  • CAS Number: 79514-49-1
  • Molecular Formula: C10H15N4Se
  • Molecular Weight: 270.21300
  • Catalog: Research Areas Cancer
  • Create Date: 2016-02-10 00:41:04
  • Modify Date: 2024-09-12 10:10:54
  • Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].

Name 1-λ1-selanyl-N,N-dimethyl-N'-[(E)-1-pyridin-2-ylethylideneamino]methanimidamide
Synonyms 2-acetylpyridine-N,N-dimethylselenosemicarbazone
2-acetylpyridine 4,4-dimethyl-3-selenosemicarbazone
2-Acetylpyridine 4,4-dimethylselenosemicarbazone
Description Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization[1].
Related Catalog
References

[1]. Zaynab Al-Eisawi, et al. Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization. J Med Chem. 2016 Jan 14;59(1):294-312.  

Molecular Formula C10H15N4Se
Molecular Weight 270.21300
Exact Mass 271.04600
PSA 40.52000
LogP 0.71610

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79514-49-1 structure

79514-49-1

Literature: Klayman; Scovill; Bartosevich; Mason European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 317 - 320

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79514-49-1 structure

79514-49-1

Literature: Klayman; Scovill; Bartosevich; Mason European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 317 - 320
Precursor  2

DownStream  0