607737-87-1

607737-87-1 structure

Name: A 77-01
Chemical Name: 4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
CAS Number: 607737-87-1
Molecular Formula: C₁₈H₁₄N₄
Molecular Weight: 286.33100
Catalog: Signaling Pathways TGF-beta/Smad TGF-β Receptor
Create Date: 2018-12-18 20:40:46
Modify Date: 2024-01-04 09:40:11
A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.

Name	4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
Synonyms	4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinolone A 77-01

Description	A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.
Related Catalog	Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer
References	[1]. Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800.