607737-87-1
607737-87-1 structure
- Name: A 77-01
- Chemical Name: 4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
- CAS Number: 607737-87-1
- Molecular Formula: C18H14N4
- Molecular Weight: 286.33100
- Catalog: Signaling Pathways TGF-beta/Smad TGF-β Receptor
- Create Date: 2018-12-18 20:40:46
- Modify Date: 2024-01-04 09:40:11
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A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01.
| Name | 4-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline |
|---|---|
| Synonyms |
4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-quinolone
A 77-01 |
| Description | A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. IC50 Value: 25 nM [1]Target: ALK5A-77-01 is a close analogue of A-83-01(Axon 1421) and has a very similar biological profile of A-83-01. A-83-01 is found to decompose to A-77-01 under certain circumstances and A-77-01 is likely an active component or metabolite of its prodrug A-83-01. |
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| Related Catalog | |
| References |
| Density | 1.254g/cm3 |
|---|---|
| Boiling Point | 481.63ºC at 760 mmHg |
| Molecular Formula | C18H14N4 |
| Molecular Weight | 286.33100 |
| Flash Point | 256.391ºC |
| Exact Mass | 286.12200 |
| PSA | 54.46000 |
| LogP | 3.99530 |
| Index of Refraction | 1.685 |
| Storage condition | 2-8℃ |